Gaser Abdelrasoul

Motivated and well-organized professional with +6 years of experience in R&D, bioanalytical and analytical chemistry, assay developments, and the design, execution, transfer, and validation of analytical experiments and stability studies. Team player thrives in cross-functional team environments with solid problem-solving and communication skills, forestalls potential issues, and initiates a fast response. Well-versed in developing cost-effective solutions to complex problems using innovative methodologies, data analysis, data validation, and documentation.

• Bioanalytical techniques for biomolecules and biomolecule-nanoparticle hybrids characterization: Tecan automated liquid handler, ELISA, SPR, gel column chromatography, electrophoresis, PCR, qPCR, flow cytometry, and cell labeling for diagnosis
• Analytical techniques for chemical molecules: UV-Vis, FTIR, DLS, NTA, wet chemistry, ICP-OES, MS, HPLC, and LC-MS for organic, inorganic, and organic-semiconducting hybrid materials
• Microscopic analytical techniques: optical microscope, TEM, SEM, SEM/EDX, and confocal laser scanning microscope
• Design, execute, and validate analytical testing, stability, and compatibility studies for pharmaceutical and biological hybrid molecules following DOE principles SOPs and safety measures EHS, GMP, and GLP
• Data collection and analysis using software such as Excel, GraphPad Prism, and OriginLab to conduct drift control and background correction for complex samples.
• Liaise between R&D and the quality control team to transfer the quality validation, production, and scaling up protocols and performance qualification documents
• Manage multiple research projects and support the technical development and troubleshooting of instruments to develop reagent kits for biotechnology and pharmaceutical applications.
• Prepare plans, scope, progress reports, and presentations; participate in meetings; communicate with other departments
• Provide guidance and training to junior scientists and technicians covering safety and health, environmental, and technical aspects.

Senior Scientist, Vital Biosciences, Mississauga ON, Canada – Sept 2022 – present

• Design and execute characterization and stability investigations for antibody-nanoparticle hybrids and active ingredients to build recognition elements for a diagnostic platform, saving 50,000 per month on outsourcing reagents
• Employ the TECAN Freedom Evo automated liquid handler to run ELISA immunoassays, gel electrophoresis, gel column chromatography, DLS, fluorescent, UV-Vis, and TEM to validate antibody complexes’ stability and compatibility, improving shelf-life over 3 months, minimizing non-specific binding, and boosting the sensitivity by 300%
• Provide training and guidance in the design and execution of ICP-OES, TEM, PL, DLS, and FTIR characterization, including troubleshooting, method implementation, and safety support.
• Create and review experimental reports, SOPs, and safety documents to support the research activities in the lab.

• Developed QA/QC testing for the developed nanocapsules and incoming active ingredients following GLP, enhancing the encapsulation efficiency
• Conducted MS, GPC, TEM, and FTIR on organic nanocapsules, DLS, and an optical microscope to confirm the encapsulation of the active small molecules 
• Documented the experimental results, wrote and updated SOPs for the new instruments, and prepared and delivered presentations summarizing the project results.

• Developed antibody-nanoparticle hybrids, designed and executed purification and characterization using column chromatography, TEM, DLS, ICP-OES, SEM, and gel electrophoresis for cell labeling and diagnostic applications, resulting in a total budget of $800,000 and two patents
• Performed qPCR, PCR, and ELISA to validate the developed antibody-nanoparticle and DNA-nanoparticle recognition elements and smart gene nanocarriers, estimating the sensitivity and stability
• Conducted HPLC, GC-MS, LC-MS, crystallization, XRD, NMR, MS, UV-Vis, PL, and FTIR analysis for active pharmaceutical ingredients to validate their structure and estimate the impurity level.
• Collaborated with a cross-functional team to build wet chemistry processes to purify and conduct stability investigations for pharmaceutical materials and antibody complexes following GMP and GLP
• Conducted data aggregation, analysis, and interpretation using different statistical methods, and wrote and reviewed technical reports.

• Performed confocal laser microscope imaging, SEM/EDX, and flow cytometry to verify the cell labeling agents, and ELISA for the immunoassay recognition elements
• Conducted qualitative and quantitative analysis using UV-Vis, FTIR, MS, ICP-OES, confocal laser scanning microscope, HPLC, LC-MS, GC-MS, TEM, SEM, fluorescent microscope, XPS, and XRD to validate the structure and properties of the developed nanoparticle hybrids and the reagents.

Ph.D.: Nanobiotechnology, Neuroscience, Drug Discovery, and Material science

Università Degli Studi DI Genova – Department of Chemistry and Industrial Chemistry, Genova, Italy, 2012

Diploma: Nanomedicine Diagnostics and Therapeutics The University of Oxford – Department of Chemistry, Department of continuous education, Oxford, UK, 2010