高通量筛选平台研究员II

该职位来源于猎聘 Position Overview/职位概述: Execute SOP-driven plate-based assays and sustain day-to-day HTS operations with high QC rigor; independently manage routine runs when required. 在SOP框架下执行板式实验并维持日常高通量平台运营与严格质控；必要时可独立完成常规运行。 Key Responsibilities/主要职责:

• Assay execution: multi-well cellular/biochemical assays, including cell culture, transfection, reagent prep, and compound/sample handling; luminescent/fluorescent readouts and CRC generation. 实验执行：在多孔板上进行细胞/生化检测，包括细胞培养、转染、试剂配制与化合物/样品处理；完成发光/荧光读数与量效分析。
• Automation and instruments: operate liquid handlers/dispensers and readers/imagers; perform routine calibration, first-line troubleshooting, and maintenance logging. 自动化与仪器：操作移液/分液与读板/成像平台；执行日常校准、一级故障排查与维护记录。
• QC and data: apply plate QC metrics, normalization, and curve fitting; use Prism/Excel/Spotfire and standard scripts (R/Python) for batch processing; produce concise reports/dashboards and maintain ELN. 质控与数据：应用板级质控指标、归一化与曲线拟合；使用Prism/Excel/Spotfire及标准脚本（R/Python）进行批处理；输出简明报告/看板并维护ELN。
• SOP adherence and improvement: follow established SOPs and contribute to periodic updates to enhance robustness, cost, and throughput. SOP执行与改进：严格遵循既定SOP，并参与周期性更新以提升稳健性、成本效率与通量。
• Operations and compliance: manage inventory/consumables; sustain an organized, safe BSL-2 lab; ensure EHS, chemical hygiene, and accurate documentation. 营与合规：管理库存与耗材；维持整洁安全的BSL2实验室；确保EHS、化学品卫生与准确合规记录。
• Coordination and communication: handle sample logistics with biology/chemistry/CROs; track plate maps/CoAs; communicate results, risks, and tradeoffs clearly to stakeholders. 调与沟通：对接生物/化学/CRO的样品物流；跟踪板图与合格证；向相关方清晰传达结果、风险与取舍。
• Decision within criteria: make standard Go/No-Go calls under predefined QC gates and escalate deviations promptly. 准化决策：在预设质控阈值内作出标准Go/No-Go判断，并对偏差及时升级汇报。 Qualifications/任职资格:
• BS with 2–5 years or MS with 0–3 years in HTS assay execution (biotech/pharma or academic screening core). 本科2–5年或硕士0–3年HTS实验执行经验（生物技术/制药或高校筛选平台）。
• Hands-on with plate-based cell culture and transfection; luminescent/fluorescent readouts; basic CRC analysis in Prism or equivalent. 练进行板上细胞培养与转染；掌握发光/荧光读数；能使用Prism等完成基础分析。
• Experience with at least one automation platform and one reader/imager; comfort with routine maintenance and first-line troubleshooting. 至少熟练一种自动化平台与一种读板/成像设备；能进行常规维护与一级故障排查。
• Working knowledge of QC metrics, normalization strategies, and plate map design; strong data hygiene and ELN discipline. 备质控指标、归一化策略与板图设计的工作知识；数据规范与ELN记录严谨。
• Clear, concise communication; time management and prioritization under milestone and budget constraints. 备清晰简洁的沟通能力；能在里程碑与预算约束下进行时间与优先级管理。