PhD Researcher in Organic Chemistry, Bioorganic Chemistry, Oligonucleotide Synthesis and Phosphoamidite Chemistry
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I am enthusiastic about organic synthesis, medicinal chemistry, biomolecular chemistry, oligonucleotide synthesis and chemical biology. My work focuses on the design and synthesis of carbocyclic nucleoside analogues as potential epigenetic modulators for cancer therapeutics.
PhD Researcher in Organic Chemistry, Bioorganic Chemistry, Oligonucleotide Synthesis and Phosphoamidite Chemistry with Professor Dr Thomas Carell at Ludwig-Maximilians-Universität, München (2022-10 – Present)
This project focused on designing and synthesising hydrolytically stable carbocyclic analogues of Decitabine, mainly as prodrug derivatives to enhance cellular uptake and bioavailability. It involved nucleoside modification, the construction of carbocyclic scaffolds for stability, and the design of prodrugs to improve membrane permeability and intracellular delivery to investigate DNA methyltransferase inhibition. The synthesis included protection-deprotection strategies and nucleoside functionalisation.
Final compounds were purified using HPLC and characterised through ¹H and ¹³C NMR, ³¹P NMR, FTIR, and LC-MS to confirm structure and purity. The prodrug analogues were tested as epigenetic probes and potential anticancer agents.
PhD in Organic Chemistry, Bioorganic Chemistry, Oligonucleotide Synthesis and Phosphoamidite Chemistry – Ludwig-Maximilians-Universität, München (2022-10)
Master's in Organic Chemistry – University of Calabar (2017-09 – 2019-06)
Bachelor in Chemistry – University of Calabar (2011-09 – 2015-09)
