Debasmita Mondal

Synthetic Organic & Medicinal Chemist | Drug Discovery | Multi-Step Synthesis

Talent

OxfordMember since October 7, 2026

Small-molecule design and synthesisTransition-metal catalysis: Pd, Ni, Fe, AuMultistep organic synthesisHeterocyclic chemistryReaction optimisation and ligand screeningSmall-molecule synthesisBiologically relevant compoundsCompound optimisationAntiviral chemistryMechanism-guided reaction designDFT-supported and Isotope labelling mechanistic studiesReaction scope and efficiency optimisationGlovebox and Schlenk-line operationsHandling air- and moisture-sensitive reagentsCryogen handling (N₂, He)Laboratory safety complianceSafe handling of reactive intermediates and new/critical solventsHPLCAutomated flash chromatographyColumn chromatographyPreparative chromatography prep-TLCCrystallizationPrecipitationNMR (1H, 13C, 2D)FTIRX-ray crystallography (XRD)Mass spectrometry (HRMS, LCMS, GC-MS)Fluorescence spectroscopyUV-visible spectroscopyHPLC method development and compound purity analysis

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Small-molecule design and synthesisTransition-metal catalysis: Pd, Ni, Fe, AuMultistep organic synthesisHeterocyclic chemistryReaction optimisation and ligand screening

About

PhD-trained synthetic organic chemist with experience in multi-step synthesis, synthetic route design, reaction optimisation and transition-metal catalysis. Experienced in synthesising biologically relevant small molecules and heterocycles, troubleshooting challenging reactions, and developing alternative synthetic approaches. Strong practical expertise in purification and compound characterisation, including HPLC, NMR, LC-MS, HRMS and XRD.

Medicinal and antiviral chemistry experience from CSIR-IICB, with additional strengths in scientific literature research, experimental planning, data interpretation and interdisciplinary collaboration.

Experience

Project Associate –I (Medicinal & Antiviral Chemistry) - CSIR-Indian Institute of Chemical Biology - Kolkata, India

(2023-08 - 2024-03)

Designed and executed multi-step synthetic routes to biologically relevant small molecules and analogues for an antiviral research programme.
Synthesised compounds from milligram to gram scale and optimised reactions through catalyst, ligand, reagent and substrate screening.
Troubleshot challenging synthetic steps and developed alternative approaches to improve reaction outcomes.
Purified compounds using HPLC, flash/column chromatography, preparative TLC and recrystallisation.
Characterised compounds using NMR, LC-MS, HRMS, GC-MS, FTIR and single-crystal XRD.
Used glovebox and Schlenk-line techniques for air- and moisture-sensitive reactions.
Collaborated with biologists and computational researchers to support compound evaluation and interpretation of biological data.
Maintained detailed experimental records and presented results and conclusions in project discussions.
Contributed to compounds showing >90% inhibition of SARS-CoV-2 in biological evaluation.

Online Chemistry Tutor - India & UK

(2024)

Deliver online teaching for GCSE, A-levels, WBCHSE, CBSE, and undergraduate students
Focus on conceptual understanding, exam-oriented problem solving, and scientific reasoning