Senior Trial Manager, University of Oxford - Department of Psychiatry, University of Oxford - Oxford, UK
(2019-02)
Oxford Precision Psychiatry Lab, Oxford Brain Health CTU
- Senior operational lead responsible for coordinating delivery of a complex international digital health programme across four countries.
- Member of the Trial Management Group, contributing to strategic planning, operational governance and programme delivery.
- Contributed to the successful £5 million Wellcome Trust funding application supporting development of the international PRADA programme.
- Established strategic research collaborations with academic and clinical partners globally.
- Leading UK and international expression of interests, feasibility and capability assessments to establish the multinational site network.
- Coordinating study start-up activities across UK and international partners, including regulatory planning, site engagement and operational readiness.
- Co-leading the Cultural Adaptation Work Package, working alongside international collaborators to adapt participant materials, web tool interface and study procedures for different languages, healthcare systems and cultural settings.
- Involvement in the Tool Development Work Package, overseeing the back-end & front-end development of an AI-enabled clinical decision support platform.
- Involvement in the Lived Experience Work Package, focusing on clinician engagement, patient and public involvement activities and user feedback to support platform refinement and implementation.
- Oversight of the pharmacogenomics workstream, overseeing refinement of the pharmacogenomics pipeline and implementation of polygenic score (PGS) generation and delivery within the trial.
- Leading the development of electronic Case Report Forms (eCRFs) and supporting study database development.
- Led operational delivery of an international multi-centre trial (PETRUSHKA Trial) across the UK, Canada and Brazil.
- Successfully activated over 50 research sites, leading site feasibility, Site Initiation Visits (SIVs), investigator training and site readiness assessments prior to recruitment.
Clinical Trial Manager, University of Oxford - University of Oxford - Oxford, UK
Translational Neuroscience and Dementia Research Group
- Established the operational infrastructure for deep and frequent phenotyping Alzheimer's disease clinical trials, including MICAD, a Phase 1b randomised, placebo-controlled, single-blind study evaluating a novel CSF-1 receptor antagonist, enabling delivery of a complex early-phase study within an NHS hospital setting.
- Coordinated complex study activities involving PET imaging, MRI, lumbar punctures, laboratory assessments and multiple participant visits, working closely with the Oxford Brain Health Clinical Research Facility, Primary Care Clinical Trials Unit and multidisciplinary hospital teams.
- Developed study-specific documentation, including study monitoring plans, data management plans, laboratory and imaging standard operating procedures (SOPs), to support compliant and efficient trial delivery.
- Led recruitment initiatives to engage under-represented and difficult-to-reach populations, establishing strong links with the Clinical Research Network (CRN) to enhance participant recruitment.
- Worked with investigators and key stakeholders to establish study milestones, monitor progress and proactively identify and mitigate risks to study delivery.
- Managed study finances, monitoring expenditure against grant funding and service level agreements while ensuring timely invoicing and financial compliance.
- Line managed and supervised research assistants, coordinating day-to-day trial activities and supporting delivery across the multidisciplinary research team.
Clinical Research Coordinator, Imperial Memory Unit - Imperial College Healthcare NHS Trust - London, UK
(2016-03 - 2019-01)
- Established the operational infrastructure for an Eli Lilly-sponsored Phase 1b Alzheimer's disease clinical trial investigating inflammatory biomarkers, enabling delivery of a novel investigational medicinal product within an NHS hospital setting.
- Coordinated complex participant pathways involving lumbar punctures, PET and MRI imaging, safety observations, serial biological sampling, neuropsychological assessments and patient-reported outcome questionnaires across multiple clinical departments.
- Managed commercial clinical trials in Alzheimer's disease, including set-up, recruitment, retention and close-out
- Liaised with sponsors, vendors and external organisations to maintain delivery of phase I to III trials
- Disseminated information about the clinical research facility through articles, talks and presentations
Assistant Research Psychologist, Neuroepidemiology and Ageing Unit - Imperial College London - London, UK
(2015-11 - 2016-02)
- Contributed to a large observational study (CHARIOT-PRO) into dementia risk factors
- Managed daily visits in the research hub, coordinating clinicians, research nurses, assistant psychologists and laboratory technicians
- Performed neuropsychological assessments and clinical interviews
Research Assistant - Royal Berkshire Hospital - Reading, UK
(2015-03 - 2015-11)
- Supported multiple research specialties across the hospital to conduct clinical trials
- Screened and consented eligible patients, collected data and maintained site files
Learning and Behaviour Specialist - The Rise Specialist School - Feltham, UK
(2014-11 - 2015-02)
- Supported teaching staff in a specialist school for children on the autistic spectrum with behavioural difficulties and complex needs
Assistant Psychologist - NHS Community Head Injury Service - Aylesbury, UK
(2012-09 - 2013-05)
- Supported the rehabilitation of individuals with acquired brain injury in group and one-to-one sessions
