Maria Binu Jacob

Pharmacology professional with 1.5 years experience in regulated preclinical research including pharmacokinetic/toxicokinetic studies, toxicity assessment, plasma stability evaluation and efficacy studies. I am currently working in the Oncology, Discovery Biology group at Syngene International Ltd, executing studies, scientific documentation and data review. I am a Certara certified NCA Analyst using Phoenix WinNonlin and I have completed Certara Fundamentals of Pharmacokinetics and Noncompartmental Data Analysis (NCA) courses.

I am currently training in PK/PD Modeling through Certara and gaining proficiency in R.

Senior Research Associate - Syngene International Ltd - Bengaluru, India

(2025-05)

Oncology, In-vivo Pharmacology, Discovery Biology

• Executed and documented preclinical in vivo studies including efficacy, PK/TK, engraftment, and tumor growth kinetics studies involving serial blood collection, endpoint monitoring, and experimental data recording.
• Collaborated with DMPK team for PK/TK analysis and calculation of NCA parameters for monoclonal antibodies using Phoenix WinNonlin
• Maintained protocol compliance through adherence to approved study protocols, SOPs, and regulated documentation practices while ensuring data integrity.
• Prepared and reviewed study-related datasets, graphs, tables, figures, reports and experimental summaries using GraphPad Prism and Microsoft Excel.
• Organized experimental records, sample tracking logs, and study-related documentation for project continuity.

Junior Research Fellow - AIMS Research Center - Bengaluru, India

(2024-08 - 2025-04)

• Continued PK/TK analysis of the chalcone compound and interpreted concentration–time data from preclinical studies.
• Performed biodistribution (BD) studies across multiple tissues to evaluate tissue distribution of the compound.
• Calculated and interpreted key NCA PK parameters using Microsoft Excel and PKSolver.
• Reviewed concentration–time profiles and PK parameters to support interpretation of exposure and tissue distribution.
• Executed preclinical efficacy and toxicity studies in rabbit and rat models for nicotinamide gel for Atopic Dermatitis
• Collected data and prepared scientific summaries, manuscript documentation, and patent documentation.

Master's Thesis - Amrita School of Pharmacy - Bengaluru, India

(2023-08 - 2024-09)

Toxicity profiling and pharmacological evaluation of novel isopropyl-tailed chalcone in a rotenone model of Parkinson's disease

• Conducted pharmacokinetic (PK), toxicokinetic (TK), and OECD toxicity studies in rats involving serial blood sampling, plasma exposure assessment, and biodistribution analysis.
• Performed plasma stability studies and preliminary PK/TK interpretations in Excel, including evaluation of concentration-time trends, compound retention, AUC, and half-life characteristics.
• Generated and interpreted preclinical datasets from efficacy, toxicity, biochemical, and histopathological studies and prepared experimental summaries, graphical data presentations, and scientific reports.

Student Trainee - Bio-IT Research and Training Centre, IBAB - Bengaluru, India

(2023-10 - 2024-09)

• Participated in biomarker-focused research projects involving biological data analysis, visualization, and interpretation workflows.
• Assisted in preparation and review of scientific summaries, presentations, graphical outputs, and research documentation for collaborative academic projects

Masters - Pharmacology - Amrita Institute of Medical Sciences and Research Center (2022-09 - 2024-12)

Bachelors - Pharmacy - Amrita Institute of Medical Sciences and Research Center (2018-07 - 2022-07)

Senior School - Bioinformatics - The Choice School (2015 - 2017)