Rashi Verma

My objective is to explore career opportunities in drug designing and development. My longer-term goal is to obtain a research career in the health or clinical science.

1.

Senior Research Fellow

Sep2019-Sep2022

(Indian Council of Medical Research, Delhi, India)

 Development of a pipeline for drug designing

 Identification of druggable target using subtractive and comparative genomics approach which majorly includes essentiality analysis, virulence analysis, network analysis, host-pathogen interaction analysis, druggability of target.

 Designing of genome scale metabolic model of pathogen for in silico gene knockout and metabolomic analysis.

 Design of potential drug or small molecule inhibitor against the proposed druggable targets via active site prediction, docking (schrodinger), molecular dynamic simulation, energy profile analysis, principle component analysis (PCA).

 In vitro validation of proposed drug through cell culture experiments such as growth analysis (growth curve, disc difussion) and virulence analysis (hydrolytice enzyme assay, biofilm formation assay, adhesion assay)

• Ph. Scholar (Biosciences and Bioinformatics) Nov2016-Jun2022

(Jamia Millia Islamia, Delhi, India)

 Drug Designing: Pipeline development, Target identification and Validation, In-silico Gene knockout, Docking, Simulation, Interaction Analysis

 System Biology: Network formation and analysis, Genome Scale Metabolic Model Reconstruction, Host-Pathogen interactome analysis, Pathway Enrichment, Gene Annotation

 Next Generation Sequencing, Transcriptomics, Microarray Data Analysis, Variant Calling, Genome Assembly

• Post M.Sc.

Trainee

Aug2015-Nov2016

 Database Development: Data mining, Data analysis, Meta analysis

 Next Generation Sequencing, Transcriptomics, Microarray Data Analysis, Variant Calling, Genome Assembly

 Friendly with Linux, R tools, Matlab, Cytoscape, COBRA toolbox

 Know the basics of Python, C++ and Java

 Machine Learning: Develop prediction model using Weka and online software

 Vaccine development, Antibody designing against interleukin responsible for autoimmune disseases

Ph. D. Biosciences

Jamia Millia Islamia (India, Delhi)

Thesis Submitted

Nov2016-June2022