Sourik Kar
M.Sc. Chemistry — Department of Chemistry, Indian Institute of Technology Kharagpur
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About
Supervisor: Professor Nilmoni Sarkar Title: Co-Assembly of Aspartame and Bile Salt and Its Effect on Lipid Membrane Investigated the self-assembly and co-assembly behavior of aspartame with bile salts (Sodium Cholate, Sodium Taurocholate, and Sodium Deoxycholate) and their interactions with phospholipid membranes.
Experience
Master's Thesis - Department of Chemistry, IIT Kharagpur - IIT Kharagpur
(2025-07 - 2026-04)
Supervisor: Professor Nilmoni Sarkar Title: Co-Assembly of Aspartame and Bile Salt and Its Effect on Lipid Membrane Investigated the self-assembly and co-assembly behavior of aspartame with bile salts (Sodium Cholate, Sodium Taurocholate, and Sodium Deoxycholate) and their interactions with phospholipid membranes.
- Prepared and characterized lipid vesicles (DMPC) as model biological membranes using thin-film hydration and probe sonication techniques.
- Performed fluorescence spectroscopy and time-resolved fluorescence studies to investigate membrane dynamics and microenvironmental changes using Coumarin-153 and DCM fluorescent probes.
- Conducted Fluorescence Lifetime Imaging Microscopy (FLIM) to study changes in fluorescence lifetime and rigidity of molecular co-assemblies.
- Utilized Time-Correlated Single Photon Counting (TCSPC) for fluorescence lifetime and anisotropy measurements and analyzed decay profiles.
- Characterized nanoscale morphology and fibril formation using Atomic Force Microscopy (AFM) and Field Emission Scanning Electron Microscopy (FESEM).
- Measured vesicle size distribution and colloidal stability using Dynamic Light Scattering (DLS).
- Analyzed experimental data to correlate molecular self-assembly with membrane interaction and fluorescence behavior.
Summer Internship - IIT Kharagpur - IIT Kharagpur
(2025-05 - 2025-07)
Title: Encapsulation Dynamics of Thioflavin T in Bile Salt (NaDC) Aggregates: A Spectroscopic Study. Supervisor: Professor Nilmoni Sarkar, IIT Kharagpur.
- During this internship, I investigated the encapsulation dynamics of Thioflavin T (ThT) in Sodium Deoxycholate (NaDC) bile salt aggregates using spectroscopic techniques.
- I also performed UV–Visible absorption and steady-state fluorescence spectroscopy to study the photophysical properties and binding behavior of ThT in bile salt aggregates.
- Determined the partition coefficient (Kp) and Gibbs free energy (ΔG) of complex formation through spectroscopic data analysis.
- Utilized femtosecond fluorescence upconversion spectroscopy to investigate ultrafast fluorescence dynamics and excited-state relaxation processes of ThT in self-assembled bile salt systems.
Teaching Experience
Provided targeted academic support in Chemistry to Higher Secondary students, helping them prepare for competitive exams (in both offline and online mode) for 3+ years.
Education
M.Sc. - Chemistry - Indian Institute of Technology Kharagpur (2024 - 2026)
B.Sc. - Chemistry - Rahara Ramakrishna Mission Vivekananda Centenary College, West Bengal State University (2021 - 2024)
Higher Secondary - St.Xavier’s Institution, Panihati
Secondary - St.Xavier’s Institution, Panihati
