Natali Mustafa

In collaboration with NPL-IBL. Phytochemical research for application of plant extracts and/or active compounds as medicines, in cosmetics and agricultures.

Senior researcher at Holland Biodiversity B.V. (2016-03 – 2024-11)

In collaboration with NPL-IBL. Phytochemical research for application of plant extracts and/or active compounds as medicines, in cosmetics and agricultures.

• NMR-based metabolomics
• HPLC-PDA
• GCMS

Post-doctoral researcher at Natural Products Laboratory, Institute of Biology, Leiden University (2020-09 – 2024-08)

• Contribution in NMR library of plant extracts
• Execution of some NADES projects
• Supervision of guest/PhD researcher

Post-doctoral researcher at Natural Products Laboratory, Institute of Biology, Leiden University (2013-03 – 2016-02)

• Development of natural deep eutectic solvents (NADES, a Leiden University patent) for applications in the field of pharmaceutical (drug formulation), food (extraction of e.g. flavors & fragrance), cosmetics (formulation), and preservation
• In collaborations with Tiofarma, LACDR, Debiopharm, LUMC, Holland Biodiversity B.V. and Hortus Botanicus Leiden
• Supervising PhD-, Msc- and Bsc- students and guest researcher
• Lab management

Senior researcher at ExPlant Technologies B.V. (2010-09 – 2012-12)

• Development of in-vitro cell and organ cultures of Catharanthus roseus for improving the production of some active compounds (medicines) and their precursors observed by HPLC-PDA, NMR & RT-PCR. (IOP Genomics & IOP valorization projects)
• Development of in-vitro cell and organ cultures of Senecio for production and isolation of some (standard) compounds (Food & Nutrition Delta project)

Post-doctoral researcher at Department of Pharmacognosy, Section Metabolomics, Institute of Biology (IBL), Leiden University (2008-01 – 2010-08)

• Combining some approaches in plant biotechnology and phytochemistry (NMR-based metabolites profiling) to study the biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus for improving the production of the anticancer vincristine, vinblastine and some precursors (EU-FP-7 'SmartCell' and NWO IBOS-ACTS projects)
• Development of Panax notoginseng & Gynura organ cultures for production of materials used in the traditional medicines and analysis of the active compounds by HPLC-PDA & NMR (Senternovem project)
• Evaluation of anti-inflammatory activity of several (medicinal) plants
• Supervising PhD and MSc students
• Managing Plant Cell Cultures Lab

Analytical Scientist at Section Plant Ecology, Institute of Biology, Leiden University (2006-10 – 2008-09)

• Developing methods for qualitative & quantitative analyses of natural products (glucosynolates in Arabidopsis plants) using HPLC-PDA and performing NMR-based metabolomics on Arabidopsis plants

PhD researcher at Department of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University (2002-04 – 2007-05)

Project: Mapping the biosynthetic pathway of salicylic acid (SA) – an important signaling compound for systemic acquired resistance in plant – using 13C isotope & NMR.

Analytical scientist at Kimia Farma Pharmaceutical Industry (1990-10 – 1991-07)

Worked under GMP/GLP, ISO 9001/14001

• Development of analytical methods of vitamins A, D, E and K in oral suspensions of multivitamin products using HPLC and UV Spectrophotometry

Management trainee at Kimia Farma Pharmaceutical Industry (1989-09 – 1990-09)

• Pharmaceutical Production Department (4 months): Supervising drug production of different dosage forms (tablet, ampule, injection, capsules, syrup, etc)
• Quality Control Department (4 months): Supervising quality control of raw material, in process control, packaging material, and storage
• Research and Development Department (4 months): Development/improvement of several analytical methods for quality control of tablets and capsules

Intern at Kimia Farma Pharmacy, Hasan Sadikin public hospital, and Carlo Erba Farmitalia Phamaceutical Industries (1988-01 – 1989-07)

• Apothecary pharmacist
• Industrial pharmacist

PhD in Biology – Department of Pharmacognosy, Section Metabolomics, Institute of Biology (IBL), Leiden University (2002-04 – 2007-05)

MSc in Natural Product and Biodiversity – Leiden Amsterdam Center for Drug Research (LACDR) (1999-09 – 2001-03)

Pharmacist in Pharmacy – Department of Pharmacy, Faculty of Natural Sciences, Bandung Institute of Technology (ITB) (1988-08 – 1989-08)

BSc in Pharmacy – Bandung Institute of Technology (1983-08 – 1988-08)