Wang Xin

I am PhD from Fujian Institute of Research On The Structure Of Matter, Chinese Academy Of Sciences. During my PhD I have published 3 papers in peer-reviewed journal, 2 with 1st author and 1 with corresponding author. Before this, I was serving as Research Associate in HJE.I.C.C.B.S, University of Karachi, under the kind supervision of Assistant Prof. Dr. Abdul Hameed and co-supervision with Prof. Dr. Khalid M.Khan (a very big name in Pakistan's Research Council). As research associate I was responsible for the synthesis and characterization of newly synthesized compound by using different analytical technique such as, NMR, IR, Mass, HRMS, Flash Column Chromatography, HPLC and Melting Point. I have published 3 papers with Dr. Abdul Hameed. My aim is to serve my life for research in Pakistan.

As research associate I have done synthesis of different project such as;

• Project No. 20-3733/NRPU/R&D/ 14/520 was supported by Netherland and Higher Education Commission Pakistan. It was published in Bioorgnic Chemistry. One-pot synthesis of 1H tetrazole linked 1,2,5,6-tetrahydronicotinonitriles under solvent-free conditions have been carried out in the presence of tetra-n-butyl ammonium fluoride trihydrated (TBAF) as catalyst and solvent. Moreover, the synthesized compounds were screened for cholinesterases (acetylcholinesterase and butyrylcholinesterase) inhibition which are consider to be major malefactors of Alzheimer’s disease (AD) to find lead compounds for further research in AD therapy. 
• Project No. 20-1910 /NRPU were supported by Higher Education Commission Pakistan and N.F. is supported by a fellowship from the Jürgen Manchot Foundation, Düsseldorf, Germany. This project was also published in Bioorgnic Chemistry. In this project we have synthesized a series of 19 benzofurane linked N-phenyl semithiocarbazones. All the compounds were screened for enzyme inhibitor activity against Jack bean urease. A docking study with Jack bean urease (PDB ID: 4H9M) revealed possible binding modes of N-phenyl thiosemicarbazones. 
• Project No. 20-1910 under NRPU and Higher Education Commission Pakistan. This Project was published in Chemical Biology & Drug Design. This project demonstrates the synthesis of pyrido[2,3-b]pyrazines series, their inhibitory activities against both cholinesterases, AChE and BChE, and molecular docking studies. Molecule docking studies of the active compounds suggested the putative binding modes with cholinesterase. The potent compounds among the series could potentially serves as good leads for the development of new cholinesterase inhibitors. 

PhD research was focused on the development of two asymmetric organic catalytic systems the kinetic resolution of two types of racemic compounds with important application values. At present, the synthesis of these quaternary compounds is challenging by direct asymmetric approaches. . The kinetic resolution of β-ketoesters via intramolecular benzoin coupling reaction catalyzed by N-Heterocyclic carbene affords a series of chiral annulation product and chiral recovered β-ketoesters with good to excellent enantioselectivity. We believe that this research work has good reference significance for the kinetic resolution of more satirically bulky and hindered groups at α-substituted esters (See Publication Section in resume). The project of classical kinetic resolution of fluorine containing compounds with quaternary carbons, by asymmetric catalytic acyl transfer reaction, and successfully obtained a series of chiral quaternary carbon fluorinated compounds with rich and diverse structures. This method shows an excellent kinetic resolution effect on perfluoro-containing compounds as well (See Publication Section in resume).