Madhu Mathy

Madhumathy specializes in high intensity and high-volume laboratory planning preparatory, analytical and executory work. Currently, Madhumathy has unique experience in Analytical methods both purity and impurity assays for the selection of cell line, cell culture medium or process, analyses the stability of antibody after purification, effectiveness of purification methods etc. Madhumathy has capabilities in both qualitative and quantitative analysis of real-time PCR data through variety of data-analysis software.

She was accorded responsibilities of performing independent analysis of PCR melt curves, as well as ascertaining and correcting procedural errors in the viral RNA detection process.Highly organized, responsible and dedicated cross functional team player, I can utilize my experience in the cGMP, aseptic processing, performing protein analysis to positively impact the organization. I have more than 2 years’ experience in biopharma industry Lonza and diagnostic lab.

A highly intellectual individual with great passion to contribute towards global human health through cellular research, disease prevention techniques and diagnostic improvements. Dedicated clinical researcher offering excellence in molecular biology techniques, including DNA sample preparation, quantitation, sequencing and protein expressions. Has gained 5-years’ experience in wet lab and knowledge in Biochemical and cell-based assays research.

Lonza Biologics Tuas PTE Ltd.

Process Analyst (PCP Trainee): Nov 2021- Present

• Responsible for executing analytical assays such as qPCR, ELISAs, ic-IEF, Protein A HPLC, GPC, CE-SDS, Caliper and providing the results in a timely manner to the respective upstream and downstream processing team.
• Perform analysis of final product, in-process samples according to Standard Operating Procedures and Test Methods.
• Documentation and review of results in accordance with current Good Manufacturing Practices (cGMP).
• Involved in equipment qualification, maintenance and troubleshooting.
• Performed Suitability assessment and conditional testing of molecules (complex molecules) to the platform methods.
• General lab support including housekeeping, equipment maintenance, inventory of supplies, lab supplies ordering
• Involved in CI project to improve the workflow
• Support sample logistics area including retention sample storage, shipment of samples.
• Prepare, maintain standards and reagents as required by GMP documents.

A*star (Singapore SDL-Stronghold Diagnostic Lab) Aug 2020-Oct 2021

Laboratory Technologist in PCR and RNA extraction Station

• Achieved 100% 24-hour turnover rate with full compliance with Standard Operating Procedure.
• Independently conducted RT-PCR runs on live sample and subsequently performed analysis on the respective Ct values and melt curves for viral RNA targets sequences.
• Responsible for troubleshooting and correcting software and instrument errors as the part of viral RNA detection process.
• Critically evaluated quality control standard within lab through various precision accuracy and validation studies, in compliance with the PHMCA and standard laboratory risk management protocol.
• Skilled in handling personal sensitive data for the preparation of clinical reports for submission to respective authorities.
• Performing RNA extraction process by coordinating with all the other workstations and adding controls in qPCR plates.
• Maintain accurate, complete and legible records. Identify discrepancies and verify documentation performed by other technologists and technicians. Review documentation for accuracy, validity and completeness
• Operating, calibrating, conducting performance checks, and maintaining any laboratory analysers qPCR equipment MGI.

Education

• Certification in PCP program modules 2021- Singapore Polytechnic
• Post diploma certificate in cell and molecular biology 2018 - Ngee Ann Polytechnic
• Bachelor of Education 2009-2010 - Tamil nadu Teacher Education
• Masters in Biochemistry 2007-2009 - Bharathidasan University
• Bachelors in Biochemistry 2004-2007 - Bharathidasan University