SCIENTIST, ANALYTICAL DEVELOPMENT at GENMARK DIAGNOSTICS, INC. ROCHE DIAGNOSTICS (2025-01 – Present)
- Performed LC-MS and UPLC method development for raw materials and reagents used in Medical Devices
- Designed, developed, optimized, and validated analytical methods for the characterization of oligonucleotides using LC-MS (RP, SEC, HILIC)
- Supported formulation development, process development, and stability studies by providing timely, high-quality analytical data and interpretation via SOPs, technical reports and summaries
- Conducted investigations and root cause analysis on product failure incidences
- Wrote SOP and Work Instructions for the onboarding and validation and maintenance of analytical instruments to ensure safety and data integrity standards were met
ASSOCIATE SCIENTIST, OLIGONUCLEOTIDE CHEMISTRY at JOHNSON AND JOHNSON INNOVATIVE MEDICINE (JANSSEN PHARMACEUTICALS) (2023-11 – 2024-03)
- Performed LC-MS systems analytical method development and optimization for novel oligonucleotides and lipid modifications
- Performed in-process and final QC for various modified oligonucleotides in support of discovery projects
- Performed daily maintenance and troubleshooting of analytical instruments; HPLC, LC-MS/UV
- Implemented new techniques for the continued development and optimization of processes and characterization methodologies
LC/MS BIOANALYTICAL CONTRACT SCIENTIST SM/BIOMARKER at Denali therapeutics (2023-03 – 2023-09)
- Developed and qualified LC-MS/MS assays; performed assay maintenance testing ofLC-MS/MS methods
- Performed bioanalysis of small molecules and biomarkers in various biological matricesincluding plasma, urine, CSF, and tissues
- Performed regular stability studies on small molecules of interest using LC-MS/MS
TRANSLATIONAL SCIENCES SR. RESEARCH ASSOCIATE at INTERVENN BIOSCIENCES (2022-12 – 2023-02)
- Designed, planned, and performed experiments for protein biomarker validation studies within timelines and maintaining high scientific, safety, and ethical standards
- Prepared scientific reports and other documents such as SOPs, and presented data reports across multifunctional science teams
- Coordinated and executed the full transition to electronic laboratory notebooks
- Established and maintained a reagent and consumables inventory system
- Trained new scientists and research associates on serum/plasma sample preparation and targeted peptide/glycopeptide qualification workflow
- Performed routine UHPLC-QQQ maintenance and troubleshooting
TRANSLATIONAL SCIENCES RESEARCH ASSOCIATE at INTERVENN BIOSCIENCES (2021-08 – 2022-12)
- Conducted experiments for the development of sample preparation, peptide separation methods, data analysis and interpretation, glycoproteomic technology evaluation, glycoproteomic software evaluation
CONTRACT QUALITY CONTROL ANALYST II at AUDENTES THERAPEUTICS (2021-01 – 2021-06)
- Implemented and executed analytical testing of AAV gene therapy drug products in support of clinical and commercial production in compliance with GMP standards
- Supported stability studies, method validation/ qualification and routine calibrations such as SDS-PAGE, Western Blots, and ddPCR
- Executed and documented material specification testing for DS/DP within specified deadlines across multiple projects
SENIOR ANALYTICAL SCIENTIST I at MICROCONSTANTS (2020-08 – 2021-01)
- Responsible for performing sample analysis by ways of liquid-liquid extraction, acid-base, solid phase extraction followed by separation and detection on LC-MS/MS or HPLC systems; performing method validations and report writing
- DMPK method validation/qualification in small molecule bioanalysis
- Responsible for training new analysts in mass spectrometer use, sample analysis, and method validation
ANALYTICAL SCIENTIST II at MICROCONSTANTS (2019-06 – 2020-08)
ANALYTICAL SCIENTIST I at MICROCONSTANTS (2018-05 – 2019-06)
LABORATORY TECHNICIAN at MICROCONSTANTS (2017-11 – 2018-05)
