Hanzhi Wu, Phd
US Permanent Resident (Green Card holder)
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About
Bioanalytical Method Development & Validation: Independently design, develop, optimize, validate, and transfer robust LC-MS/MS and high-resolution mass spectrometry (HRMS) methods for the quantitative analysis of large molecules, oligonucleotides, proteins/peptides, antibody-drug conjugates (ADCs), and other biotherapeutics across diverse biological matrices, dosage forms, and drug delivery systems.
Technical
Innovation & Cross-Functional Troubleshooting: Led troubleshooting efforts for complex LC-MS/MS and HRMS analytical issues, minimizing study delays and improving laboratory throughput. Drive the development of innovative analytical technologies, evaluate/integrate new instrumental capabilities, and provide critical cross-functional technical support to production and project teams to resolve challenging in-study sample failures.
Scientific Leadership & Documentation: Author, review, and critically evaluate study protocols, project progress reports, final study reports, and other project-related technical documentation to ensure scientific rigor, quality, and compliance.
Experience
Research Scientist - THERMO FISHER SCIENTIFIC (PPD) - Middleton, WI, USA
(2022-01)
- Bioanalytical Method Development & Validation: Independently design, develop, optimize, validate, and transfer robust LC-MS/MS and high-resolution mass spectrometry (HRMS) methods for the quantitative analysis of large molecules, oligonucleotides, proteins/peptides, antibody-drug conjugates (ADCs), and other biotherapeutics across diverse biological matrices, dosage forms, and drug delivery systems.
- Technical Innovation & Cross-Functional Troubleshooting: Led troubleshooting efforts for complex LC-MS/MS and HRMS analytical issues, minimizing study delays and improving laboratory throughput. Drive the development of innovative analytical technologies, evaluate/integrate new instrumental capabilities, and provide critical cross-functional technical support to production and project teams to resolve challenging in-study sample failures.
- Scientific Leadership & Documentation: Author, review, and critically evaluate study protocols, project progress reports, final study reports, and other project-related technical documentation to ensure scientific rigor, quality, and compliance.
Associate Staff Scientist - WAKE FOREST BAPTIST MEDICAL CENTER - Winston-Salem, NC, USA
(2020-07 - 2021-11)
- Comprehensive Protein Characterization & PTM Analysis: Expertly execute advanced workflows for protein characterization, including intact protein molecular weight measurement, enzymatic digestion (in-gel/in-solution), and high-resolution peptide mapping. Highly proficient in qualitative and quantitative analysis of post-translational modifications (PTMs), with specialized expertise in phosphorylation, glycation, and complex cysteine redox proteomics (sulfenylation, nitrosylation, and disulfide b
- High-Dimensional Quantitative Proteomics: Formulate and execute diverse absolute and relative quantification strategies for targeted proteins and large-scale proteomes, utilizing advanced multiplexing technologies such as Tandem Mass Tagging (TMT), SILAC, label-free quantification, and targeted SRM/PRM analysis.
Research Fellow - WAKE FOREST BAPTIST MEDICAL CENTER - Winston-Salem, NC, USA
(2015-01 - 2020-07)
- Comprehensive Protein Characterization & PTM Analysis: Expertly execute advanced workflows for protein characterization, including intact protein molecular weight measurement, enzymatic digestion (in-gel/in-solution), and high-resolution peptide mapping. Highly proficient in qualitative and quantitative analysis of post-translational modifications (PTMs), with specialized expertise in phosphorylation, glycation, and complex cysteine redox proteomics (sulfenylation, nitrosylation, and disulfide b
- High-Dimensional Quantitative Proteomics: Formulate and execute diverse absolute and relative quantification strategies for targeted proteins and large-scale proteomes, utilizing advanced multiplexing technologies such as Tandem Mass Tagging (TMT), SILAC, label-free quantification, and targeted SRM/PRM analysis.
Engineer - School of Life Science, Xiamen University - Fujian Province, China
(2004-08 - 2008-10)
Research Assistant - Chemistry Department, Hong Kong Baptist University - Hong Kong, China
(2009-01 - 2009-10)
Education
PhD - Analytical Chemistry - Hong Kong Baptist University (2010-01 - 2014-10)
Master - Biochemistry and Molecular Biology - School of Life Science, Xiamen University (2001-09 - 2004-07)
Bachelor - Biochemistry - Fuzhou University (1995-09 - 1999-07)
Exchange Student - Chemistry - University of Missouri-Columbia (2012-11 - 2013-05)
