Vadanasundari Vedarethinam

A highly professional scientist with proven experience in biomedical applications over 6 years for disease diagnostic devices and various biomedical applications. Enormous experiences in analysis of biomarker detection . Excellent interpersonal skills to communication and collaborate effectively with coworkers. Strong interpersonal skills and recognized for professionalism, commitment, and dedication to excellence.

EXPERIENCE

Weill Cornell Medicine,

Postdoctoral research associate

• Development and preclinical validation of small molecule cancer therapeutics

• Working analytical skills in identifying fibroblast activation protein (FAP) in animal models from bladder cancer mouse

• Molecular therapeutics screening (in vitro and in vivo model)

• Preclinical tumor imaging contrast for clinical applications

• Analytical experiments in peptide synthesis, purification,

and identification by HPLC and mass spectrometry

• Formulation of cyanine 5.5 and FAP inhibitor conjugated with peptides for targeted drug delivery and imaging

• Mammalian cell culture and FAP protein identification by cell sorting using flowcytometry

• Cell lysis and protein extraction and identification by mass spectrometry

• Tumor implantation to mouse model for FAP targetted drug delivery and molecular imaging by cyanine 5.5

conjugated peptide

• Biochemical analysis of drug delivery system in a mouse model

• Design, plan and execute experiments

• Manage projects, record and data analysis

• Write research papers, proposals, reviews, and reports

• Organize product and materials testing.

Nanomaterials

Characterization

• Biophysical methods (DLS/Zeta/XRD/XPS/TEM/SEM).

• Chromatographic methods (TLC, HPLC, UV-Vis

Spectroscopy, Mass Spectrometry)

• Analytical method validation

Microbiology

• Bacterial culture

• Media formulation and optimization

• protein extraction and purification

• Metabolites extraction and molecular determination

• Bacterial growth inhibition assay

• Microscopic analysis.

EDUCATION

Shanghai Jiao Tong University,

Postdoc fellow

• Nano-Formulation project (Metal NPs/ polymer hybrids/ micelles/ Peptide-PEG-PLGA NPs)

• Biomolecule (proteins, amino acids, carbohydrates,

small metabolites, lipids, organic compounds)

identification by mass spectrometry

• Nanoparticle-mediated cancer biomarker detection from cancer cell lines and human biofluid samples

• Formulation of drug/ ligand/fluorescent dye conjugated nanoparticles for targeted receptor protein detection and separation

• Nanoparticles physical & chemical analysis and characterization

• Product purification and analysis of drug-conjugated nanoparticles

• Metabolites and protein extraction from biofluids and molecular analysis by mass spectrometry and determination by human metabolome database

(HMDB)

• Bacterial cultivation with optimized media formulation for protein extraction and identification by mass spectrometry

• Small molecules (< 1000 m/z) extraction from bacteria and identification by HMDB

• Responsible for scientific communications (papers,

conference abstracts, seminars)

• Laboratory maintenance

• Obtaining research fundings

• Training and mentorship of undergraduate students.

Ph.D Researcher

• Preclinical validation for the delivery of synthetic molecule for HCC

• Histopathological analysis of HCC tumor tissue

• Tissue homogenization, cell lysis, and protein extraction

• Proteomic evaluation of elevated HCC biomarkers

Education

PRIST University, TN, India Ph.D. Biotechnology Engineering 

PRIST University, TN, India M. Tech. Biotechnology Engineering 

Bharathidasan University, TN, India M. Sc. Biotechnology 

Bharathidasan University, TN, India B.Sc. Nutrition & Dietetics