Naka Kadri

Research Engineer in organic chemistry, specialized in the design, synthesis, purification, and characterization of bioactive organic molecules and heterocyclic compounds. Experienced in multi-step organic synthesis, reaction optimization, chromatographic purification, and structural elucidation using NMR, IR, HRMS, and HPLC. Involved in the development of therapeutic candidates through structure–activity relationship (SAR) studies, including anticancer projects (Sfax, Tunisia), antimalarial compounds (Toulouse, France), and antileishmanial agents (Nantes, France).

Rigorous, proactive, and collaborative, with strong analytical and problem-solving skills in multidisciplinary research environments.

Internship – Master's Thesis at Coordination Chemistry Laboratory (LCC) – CNRS (2023-03 – 2023-08)

• Synthesis of novel antimalarial compounds using multi-component reactions (MCRs) for rapid access to bioactive heterocycles
• Design and preparation of antimalarial candidates, including syncarpic acid derivatives
• Application of green chemistry strategies and optimization of reaction conditions and purification to improve yields

Trainee at IICiMed, Therapeutic Chemistry Laboratory (UR 1155), UFR Pharmacy – Nantes Université (2024-09 – 2024-12)

• Hit-to-lead identification and rational design of bioactive small molecules with anticancer and antileishmanial activity
• Molecular docking, ligand–protein interaction analysis and structure-based drug design (SBDD)
• ADMET-driven lead optimization (physicochemical properties, drug-likeness, pharmacokinetic profiling)
• Chemical space exploration and pharmacophore-guided design of novel therapeutic scaffolds
• Multi-step organic synthesis of drug candidates, including anticancer agents, antileishmanial compounds and PROTAC degrader

Current Internship Project at University of Nantes (2025-09 – Present)

Structural and functional study of Leishmania CK1.2, Investigation of intracellular signaling pathways for identification of potential therapeutic targets in host-directed and antiparasitic strategies.

Co-supervisor, Master Diploma at University of Nantes (2026-03 – 2026-12)

Synthesis and structural characterization of coumarin–urea derivatives as antiplatelet agents: in vitro and in silico evaluation of biological activity and toxicity

Bachelor's Degree in Chemistry in Chemistry – Faculty of Sciences of Sfax (2018-09 – 2021-06)

Research Master in Organic Chemistry in Organic Chemistry – Faculty of Sciences of Sfax (2021-09 – 2023-12)