Dr Yellaiah Tangella

Accomplished Synthetic Organic Chemist with 10 years of industrial research experience in CRO/CDMO/API environments, specializing in API process development. Expertise in route scouting, Feasibility, Optimization, impurity profiling, route design for impurity synthesis and small molecules, and scale-up from milli-gram to multi-kilogram scale. Proven track record of designing robust, scalable, and cost-effective synthetic processes to support commercial API manufacturing and regulatory submissions.

Strong Knowledge in plant trouble shootings, impurity control strategies, regulatory documentation, and implementation of greener and economically viable processes. Recognized for leading cross-functional teams and delivering high-quality results under stringent timelines. Author of 25+ peer-reviewed international publications.

Scientific Skills and Technical Exposure

• Route scouting and RMC analysis:Proficient in identifying alternative synthetic pathways and preparing RMC sheets for cost evaluation, raw-material planning, and process optimization in API development.
• API process development: Expertise in developing, optimizing, and scaling up synthetic route for APIs, KSMs, and advanced intermediates.
• Process optimization:Skilled in process design, reagent/solvent selection, yield improvement, and troubleshooting reaction issues to enhance robustness and reduce impurity formation.
• Documentation and reporting:Experienced in preparing technical, development, and manufacturing reports, and collaborating with cross functional teams to ensure clear communication and timely project execution.
• Regulatory & Safety Awareness:Capable of designing cost-effective, safe, and regulatory-complaint process for commercial API manufacturing; familiar with GMP/Non-GMP environments and process-hazard assessment.
• Analytical Techniques: Proficient in reaction monitoring (TI.C, LC-MS, HFI.F.) and purification techniques; skilled in interpreting NMR, MS, IR, UV-Visible, and XRD data.
• DoE & Process Understanding: Hands-on experience with DoF.-based optimization and process evaluation for scalability and reproducibility.
• Medicinal Chemistry & Synthesis: Specialized in medicinal chemistry with practical experience in multi-step synthesis from gram to multi-kilogram scale; adept in designing and synthesizing new chemical entities (NCEs).

• Software&DigitalTools:

Chemical drawing&designtools:ChemDraw

Literature&patentdatabases:Science Direct,Pub Med,Reaxys,SciFinder

Productivitytools:Microsoft Office(Word,Excel,PowerPoint)

• Multi-step heterocyclic synthesis, route scouting, alternate route design.
• Development of efficient, scalable, and cost-effective synthetic pathways
• Organocatalysis and C–H functionalization methodologies
• Development of metal-free synthetic transformations
• Handling of air- and moisture-sensitive reactions using inert atmosphere techniques 
• Reaction optimization to enhance yield, selectivity, and reproducibility
• Route scouting, RMC-based cost evaluation, and process optimization.
• Impurity identification, synthesis, and control strategies.
• Scale-up validation, technology transfer, plant troubleshooting.
• Preparation of GTI and NDSRI documentation for regulatory submissions
• Effective response to regulatory deficiencies and technical queries
• Implementation of cost improvement processes (CIP) and yield enhancement strategies

Ph.D. in Organic Chemistry with specialization in complex molecule synthesis, retrosynthetic analysis, reaction mechanism studies, and scalable process development. Extensive experience in analytical characterization and scientific documentation for regulated environments