Hrebesh Subhash

As an accomplished and versatile leader in advanced digital clinical method development and transnational clinical research, I offer over 15 years of experience in architecting diagnostic and connected health devices from concept to commercialization. My research interests center around cutting-edge biophotonics technologies and tools to collect clinical data and biological insights into clean, actionable data for integration, visualization, and analysis, with a focus on digitizing clinical development and clinical trials.

I specialize in the vertical integration of multiple disciplines, including photonics, optical imaging, electrical engineering, signal processing, micro-nano technology, biology, and clinical technology. I have a deep background in research and development, with expertise across a wide range of optical imaging systems, wearable sensor technologies, medical devices, on-device intelligence, biosensors, hybrid sensor fusion platform developments, image and signal processing, machine learning, and artificial intelligence.

My extensive knowledge of innovative digital tools and techniques, including wearables, digital health technologies, data capture and data analytics methods, machine learning, and artificial intelligence, allows me to effectively address the challenges faced in drug discovery and consumer product development. I have a practical understanding of how to leverage these tools to provide recommendations and insights based on case studies across consumer clinical products, and I am able to accelerate the translation of scientific discoveries from the bench to medical care.

Throughout my career, I have navigated healthcare and technology’s adjacent and evolving landscapes, with a focus on wearable sensors, connected health devices, and AI in clinical trial research and patient outcome research. I am passionate about challenging traditional boundaries and building useful products for patients, consumers, and providers while innovating within a sustainable business model. My multidisciplinary approach, integrating technologies such as AI, imaging, consumer electronics, and optics, is driven by my desire to transform healthcare and support people, products, and businesses from development to expansive growth.

Published artifacts include 10+ issued patents (20 pending patents), 150 journal papers & conference papers, and 5 book chapters (3000+ citations)

Colgate-Palmolive Company, Global Technology Center, NJ

Scientific Team Lead – Global Devices & Clinical Method Development

2016–Present

Lead cross-functional teams in developing and implementing digital clinical methods and biomarkers for clinical trials. Responsible for end-to-end clinical study design, vendor management, and technology implementation across global operations.

Key Achievements & Responsibilities:

• Led development and validation of innovative digital clinical methods for clinical trials, including connected device platforms with integrated sensors
• Managed end-to-end clinical study design, implementation, and analysis of novel digital health technologies
• Directed vendor selection, qualification, and management for digital biomarker implementations
• Developed cloud-based clinical image data processing pipelines for quantitative clinical outcome research
•  Led strategic collaborations with academic and commercial partners to advance R&D capabilities
• Implemented machine learning and AI solutions for clinical data analysis and predictive modeling
• Mentored multidisciplinary teams of clinical scientists, data scientists, and healthcare researchers
• Successfully managed multiple complex clinical programs simultaneously while maintaining regulatory compliance
• Developed and validated patient-reported outcomes and digital endpoints for health monitoring
• Led clinical trials of connected health technologies and therapeutic products

Spanish Council for Scientific Research (CSIC) & MIT + Madrid Vision Consortium, Spain

Senior Investigator

2015–2016

• Led development of innovative digital imaging technologies for clinical applications
• Advanced digital imaging biomarker methodologies using novel optical coherence tomography platforms
• Collaborated with international research teams on technology validation and implementation

Compact Imaging Inc. (USA) & National University of Ireland, Galway

Senior Lead Scientist / Senior Research Fellow

2012–2015

• Directed the development and clinical validation of digital imaging biomarkers and point-of-care diagnostic devices.
• Oversaw vendor relationships and ensured successful technology transfer and study execution.

Oregon Health and Science University, Portland, OR

Senior Research Associate

2010–2012

• Developed and implemented advanced imaging endpoints in preclinical and clinical studies, collaborating with multidisciplinary teams in the area of ophthalmology, neuroscience, otology and dermatology.
• Developed highly innovative clinical imaging technologies for clinical diagnostic applications

• PhD in Human Sensing & Functional Sensor Engineering

Yamagata University, Japan | 2004-2008

• MPhil in Photonics Technology

Cochin University of Science & Technology, India | 2002-2004

• MS in Applied Electronics

Bharathiar University, India | 1998-2000

• BS in Applied Electronics

Kerala University, India | 1994-1998