Jack Shayevich

Hardworking and dedicated pre-clinical research technician and researcher who recently received his Masters in Business administration. Currently looking for a role that will utilize all of my skills to the best of my abilities. Open to new and exciting opportunities in the biotechnology field.

Associate Scientist, in-vivo CAR-T/Immunology - Averna Therapeutics - 134 Coolidge Ave #2, Watertown, MA 02472

(2025-03)

• Organized, managed and executed in-vivo studies for cancer and immuno-oncology models. Performed tests for various in vivo CAR-T immunotherapies.
• Work with the lead scientists to design and execute in-vivo studies and report scientific findings for immunology, delivery and platform teams.
• Detailed documentation and record keeping via Microsoft excel and various electronic lab notebooks.
• Applied in-vivo techniques such as intraperitoneal, intravenous, subcutaneous dosing, blood collection, tumor monitoring via IVIS, necropsy, tissue collection.
• Tissue processing (Blood, spleen, bone marrow) for flow cytometry (FACS) and genomics isolation. Assisted in staining and running for FACS and well as cell counting.
• Some experience in cell culture including passaging, expansion and thaw for engraftment. Daily maintenance of various cell lines.
• Used IVIS imaging software, GraphPad Prism, and Excel to procure and graph data.

Principal Research Associate, in-vivo Pharmacology - Moderna Therapeutics - 325 Binney Street, Cambridge, MA 02142

(2023-02 - 2025-03)

• Worked as study director on in-vivo studies involved in mRNA delivery via Lipid Nanoparticles
• Ran experiments with platform delivery, infectious diseases and genomics groups
• Performed dosing, sample collections and necropsies as required for the investigator
• Performed IVIS image analysis and graphed data via GraphPad and PRISM
• Assisted as a trainer for new research associates on proper laboratory techniques
• Managed outsourcing at CRO's (Coordination, protocol design, execution and shipping)
• Managed internal animal shipments and ordering for pharmacology group

Principal Research Associate, Pharmacology - Moderna Therapeutics - 325 Binney Street, Cambridge, MA 02142

(2022-08 - 2023-02)

• Member of Pharmacology Platform team.
• Worked and assisted in in-house platform delivery studies both in-vivo and In-Vitro.
• Provided study support for in-vivo pharmacology team with dosing and necropsies.
• Assisted scientists in in-vitro downstream assays such as Western Blotting, ELISA and q-PCR.
• Provided input in scientific meetings regarding platform delivery and gave insight on study optimization.
• Managed study operations and coordination regarding in-vivo CRO studies with Non Human Primates.
• Managed storage of study tissue through use of Smartsheet and Excell.

Associate Scientist in-vivo Toxicology - Alnylam Pharmaceuticals - 675 West Kendall Street, Cambridge, MA 02142

(2021-10 - 2022-07)

• Work as director, coordinator and technician on in-vivo studies proposed by the Early Development Group.
• Develop study protocols, amendments and deviations in a GLP manner.
• Guide pre study meetings investigator communications.
• Organizes pre-study activities such as scheduling, test article formulation, dose calculations, animal ordering and study approval.
• Execute study procedures such as clinical observations, bodyweights, randomization and animal dosing.
• Use of electronic data capture system Pristima for collection as well as Excell.
• Perform necropsies and tissue collection for histology and frozen analysis.
• Processing of blood and tissue samples after collection.
• Final Quality assurance checks on studies post completion.

Research Technician II - Charles River Laboratories at Merck Research Laboratories - 33 Avenue Louis Pasteur, Boston, MA 02115

(2019-10 - 2021-10)

• Worked on various Pharmacokinetic, Oncology and Neuroscience animal models.
• Performed in-vivo procedures on mice and rats.
• Dosing methods include oral gavage, subcutaneous injection, ip injection, anal injection and intravenous injection.
• Data collection on excel including bodyweights, blood glucose, proteinurea, body condition and clinical observations.
• Blood collection in mice via submandibular, retro-orbital, tail tip and tail vein.
• Blood collection in rats via tail vein, jugular vein and cardiac stick.
• Performed necropsies and removal of necessary organs and tissues including Liver, Spleen, Kidneys, Brain, Lungs, Lymph Nodes, Bones and bone marrow.
• Skilled in BAL collection in rodents, Perfusion and CSF.

Research Technician I - Charles River Laboratories - 334 South St, Shrewsbury, MA 01545

(2018-05 - 2019-10)

• Lead technician and assistant technician on in-vivo studies.
• Collection and recording of data on laboratory software (Provantis and Mapapp).
• Proper use of Good Laboratory Practice (GLP) and non-GLP methods.
• Collection of Blood Samples from laboratory animals including Non-Human Primates, Canines, Rats and Mice via Cephalic, Femoral, Saphenous and Tail Vein.
• Collection of Feces and Urine samples.
• Monitoring food consumption both pre and post dosing.
• Proper preparation and dosing with Test Article via Oral Gavage, Intravenously and subcutaneous dosing.
• Proper restraint and acclimation of laboratory specimen in a humane manner.
• Closely following Standard Operating Procedures (SOP's), laboratory protocols and writing proper deviations.
• Sample processing skills such as micropipetting, centrifugation and sample storage.
• Maintained a solid working relationship with colleagues, investigators and sponsors.

Technician I - Charles River Laboratories - 251 Ballardvale St, Wilmington, MA 01887

(2017-05 - 2018-05)

• Sample processing skills such as micropipetting, centrifugation and sample storage.
• Working in Gnotobiotics department.
• Dealing with specimen containing specific strains of microorganisms and bacteria inside of quarantine isolators.
• Laboratory inventory, sterilization and sampling.
• Animal husbandry, production breeding and welfare.
• Working with GEM's (Genetically engineered models) of Rats and Mice of specific strains.

Summer Internship - Norwood Hospital - 800 Washington St, Norwood, MA 02062

(2013-05 - 2013-09)

• Front desk registrar for patients.
• Guided patients to proper hospital destinations.
• In charge of patient hospitality.

Summer Internship - Newton-Wellesley Hospital - 2014 Washington St, Newton, MA 02462

(2012-05 - 2012-09)

• Responsible for lab equipment storage and maintenance at Pathology laboratory.
• In charge of shipping, storage and delivery of medical supplies.

Masters In Business Administration - Biotechnology & Innovation - Husson University, Maine (2019 - 2021)

B.S - Biology/Biotechnology - University of Massachusetts, Lowell (2014 - 2018)

Ashland High School (2010 - 2014)