Mark A. Matulenko, PhD

Senior level organic chemist in Global Medicinal Chemistry (GMeC) with over 30 years' experience in the synthesis of biologically active natural and non-natural products. Presently, research duties involve creating, improving, and applying synthetic organic methods to produce essential pre-clinical intermediates and APIs in quantities ranging from milligrams to hundreds of grams. As the chemistry lead within the Centralized Organic Synthesis Group (COSG), key responsibilities encompassed partnering with medicinal chemistry teams to reach pre-clinical objectives; collaborating with process chemistry teams to develop scalable synthetic methodologies for early-stage, kilogram-scale development projects, and managing the productivity, goal-setting and skills training of up to 3 junior staff and 12 CRO chemists.

These initiatives have covered therapeutic fields such as neuroscience (including pain and Parkinson's disease), oncology, and immunology. Before 2013, I functioned as a medicinal chemist developing lead compounds for neuroscience (pain), urology (erectile dysfunction), and antiviral (HCV) projects.

Principal Research Scientist I - ABBVIE, INC. - North Chicago, IL 60064

(1995-08 - 2025-11)

Senior level organic chemist in Global Medicinal Chemistry (GMeC) with over 30 years' experience in the synthesis of biologically active natural and non-natural products. Presently, research duties involve creating, improving, and applying synthetic organic methods to produce essential pre-clinical intermediates and APIs in quantities ranging from milligrams to hundreds of grams. As the chemistry lead within the Centralized Organic Synthesis Group (COSG), key responsibilities encompassed partnering with medicinal chemistry teams to reach pre-clinical objectives; collaborating with process chemistry teams to develop scalable synthetic methodologies for early-stage, kilogram-scale development projects, and managing the productivity, goal-setting and skills training of up to 3 junior staff and 12 CRO chemists.

These initiatives have covered therapeutic fields such as neuroscience (including pain and Parkinson's disease), oncology, and immunology. Before 2013, I functioned as a medicinal chemist developing lead compounds for neuroscience (pain), urology (erectile dysfunction), and antiviral (HCV) projects.

• Awarded ACS Hero of Chemistry (2023) for the discovery of Mavyret for the treatment of HCV
• Awarded Abbott President's Award (2001) for the identification of ABT-724
• Authored 31 peer reviewed papers
• Inventor of 25 patents

AbbVie Postdoctoral Research Fellow - EMORY UNIVERSITY - Atlanta, GA 30322

(2016-02 - 2016-03)

Research Topic: Collaborated with the Center for Selective C-H Functionalization (CCHF). Conducted research on methodologies related to chiral Rh2(DOSP)4 C-H insertions into small ring saturated heterocycles.

• Research Advisor: Professor H. M. L. Davies, PhD

American Cancer Society Postdoctoral Fellow - COLORADO STATE UNIVERSITY - Fort Collins, CO 80523

(1993-08 - 1995-08)

Research Topic: 1. Completed the total synthesis of tetrahydropalmatine. 2. Completed the total synthesis of canadine. 3. Conducted research on methodologies related to chiral formamidine chemistry.

• Research Advisor: Professor A. I. Meyers, PhD
• Awarded postdoctoral fellowship from the American Cancer Society (1992; accepted)
• Awarded postdoctoral fellowship from the National Institutes of Health (1992; declined)
• Authored 1 peer reviewed paper

Graduate Research Assistant - UNIVERSITY OF WISCONSIN - Madison, WI 53706

(1987-08 - 1993-08)

Research Topic: 1. Completed the total synthesis of indanomycin. 2. Completed a partial total synthesis of breynolide. 3. Conducted research on methodologies related to the Claisen rearrangement.

• Research Advisor: Professor S. D. Burke, PhD
• Awarded US Department of Education Fellow (1992)
• Authored 4 peer reviewed papers

Undergraduate Research Assistant - UNIVERSITY OF FLORIDA - Gainesville, FL 32611

(1983-01 - 1987-05)

Research Topic: 1. Conducted research on methodologies related to small ring compounds containing fluorine (Dolbier). 2. Completed the synthesis of the betaine dye ET(30) (Gabrielsen)

• Research Advisors: Professor W. R. Dolbier, Jr., PhD and Professor B. Gabrielsen, PhD
• Authored 1 peer reviewed paper

American Cancer Society Postdoctoral Fellow - Organic Chemistry - Colorado State University (1995-08)

PhD - Organic Chemistry - University of Wisconsin (1993-08)

BS - Chemistry - University of Florida (1987-05)