Maria Binu Jacob
Pharmacology professional with 1.5 years experience in regulated preclinical research
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About
Pharmacology professional with 1.5 years experience in regulated preclinical research including pharmacokinetic/toxicokinetic studies, toxicity assessment, plasma stability evaluation and efficacy studies. I am currently working in the Oncology, Discovery Biology group at Syngene International Ltd, executing studies, scientific documentation and data review. I am a Certara certified NCA Analyst using Phoenix WinNonlin and I have completed Certara Fundamentals of Pharmacokinetics and Noncompartmental Data Analysis (NCA) courses.
I am currently training in PK/PD Modeling through Certara and gaining proficiency in R.
Experience
Senior Research Associate - Syngene International Ltd - Bengaluru, India
(2025-05)
Oncology, In-vivo Pharmacology, Discovery Biology
- Executed and documented preclinical in vivo studies including efficacy, PK/TK, engraftment, and tumor growth kinetics studies involving serial blood collection, endpoint monitoring, and experimental data recording.
- Collaborated with DMPK team for PK/TK analysis and calculation of NCA parameters for monoclonal antibodies using Phoenix WinNonlin
- Maintained protocol compliance through adherence to approved study protocols, SOPs, and regulated documentation practices while ensuring data integrity.
- Prepared and reviewed study-related datasets, graphs, tables, figures, reports and experimental summaries using GraphPad Prism and Microsoft Excel.
- Organized experimental records, sample tracking logs, and study-related documentation for project continuity.
Junior Research Fellow - AIMS Research Center - Bengaluru, India
(2024-08 - 2025-04)
- Continued PK/TK analysis of the chalcone compound and interpreted concentration–time data from preclinical studies.
- Performed biodistribution (BD) studies across multiple tissues to evaluate tissue distribution of the compound.
- Calculated and interpreted key NCA PK parameters using Microsoft Excel and PKSolver.
- Reviewed concentration–time profiles and PK parameters to support interpretation of exposure and tissue distribution.
- Executed preclinical efficacy and toxicity studies in rabbit and rat models for nicotinamide gel for Atopic Dermatitis
- Collected data and prepared scientific summaries, manuscript documentation, and patent documentation.
Master's Thesis - Amrita School of Pharmacy - Bengaluru, India
(2023-08 - 2024-09)
Toxicity profiling and pharmacological evaluation of novel isopropyl-tailed chalcone in a rotenone model of Parkinson's disease
- Conducted pharmacokinetic (PK), toxicokinetic (TK), and OECD toxicity studies in rats involving serial blood sampling, plasma exposure assessment, and biodistribution analysis.
- Performed plasma stability studies and preliminary PK/TK interpretations in Excel, including evaluation of concentration-time trends, compound retention, AUC, and half-life characteristics.
- Generated and interpreted preclinical datasets from efficacy, toxicity, biochemical, and histopathological studies and prepared experimental summaries, graphical data presentations, and scientific reports.
Student Trainee - Bio-IT Research and Training Centre, IBAB - Bengaluru, India
(2023-10 - 2024-09)
- Participated in biomarker-focused research projects involving biological data analysis, visualization, and interpretation workflows.
- Assisted in preparation and review of scientific summaries, presentations, graphical outputs, and research documentation for collaborative academic projects
Education
Masters - Pharmacology - Amrita Institute of Medical Sciences and Research Center (2022-09 - 2024-12)
Bachelors - Pharmacy - Amrita Institute of Medical Sciences and Research Center (2018-07 - 2022-07)
Senior School - Bioinformatics - The Choice School (2015 - 2017)
