Lin Yun Tan

Chemistry master's graduate from NUS with hands-on medicinal chemistry research spanning compound design, multistep synthesis, purification, analytical characterisation and cell-based evaluation. Experienced in planning experiments, investigating unsuccessful reactions, interpreting results and communicating technical findings.

Graduate Researcher, Medicinal / Bioorganic / Organic Chemistry at National University of Singapore (2023-08 – Present)

• Designed and synthesized TEAD-targeting compounds, varying their chemical structures to test how specific changes affected biological activity.
• Performed multistep synthesis, compound purification and analytical characterisation; troubleshot low-yielding or unsuccessful transformations and adjusted routes and purification approaches based on experimental findings.
• Evaluated compounds in U2OS GFP–TEAD4 cell models and interpreted Western blots, identifying compounds with dose-dependent TEAD4 and pan-TEAD reduction after 48 hours
• Documented experimental rationale, outcomes and limitations; communicated findings to chemistry and biology collaborators through research summaries, presentations and thesis writing.

Undergraduate Honors Researcher, Medicinal Chemistry at National University of Singapore (2022-07 – 2023-04)

• Continued an HDAC6 inhibitor research programme exploring small-molecule candidates for hepatitis B treatment, building on earlier work on Nexturastat A and Tubastatin A analogues.
• Performed related multistep organic synthesis and laboratory work, including reaction monitoring, purification and compound characterisation, to support structure–activity exploration.

Master's degree in Chemistry – National University of Singapore

Bachelor of Science in Chemistry – National University of Singapore